3-(Methylsulfonyl)phenylboronic acid → HCID 16660742, compound

HRID 1443096Notes

Reaction equation

HRID 1443096 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[CH3:13][S:14]([C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15].[NH2:26][C:27]1[N:28]=[C:29]([CH3:32])[S:30][CH:31]=1>>[CH3:13][S:14]([C:17]1[CH:18]=[C:19]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:26][C:27]3[N:28]=[C:29]([CH3:32])[S:30][CH:31]=3)=[N:3][CH:4]=2)[CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]

Participants

4

Reactant 3

HCID 27735423-(Methylsulfonyl)phenylboronic acidHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16660742HCID 16660742, compound

Procedure

The title compound, MS: m/e=417.2 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), (3-methylsulfonylphenyl)boronic acid and 4-amino-2-methylthiazole (Example C).

Sources & evidence

ORD record
ord-5e191674dd0a47e69f5c8f3dcc3a6f03
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

Loading…