3-Bromo-5-methylpyridine → HCID 16660903, compound

HRID 1443099Notes

Reaction equation

HRID 1443099 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.Br[C:16]1[CH:17]=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=1.[NH2:23][C:24]1[N:25]=[C:26]([CH3:29])[S:27][CH:28]=1>>[CH3:11][C:9]1[S:10][C:6]2[C:5]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=3)=[CH:4][N:3]=[C:2]([NH:23][C:24]3[N:25]=[C:26]([CH3:29])[S:27][CH:28]=3)[C:7]=2[N:8]=1

Participants

4

Reactant 3

HCID 8177133-Bromo-5-methylpyridineHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 57416436(4-Chloro-2-methyl[1,3]thiazolo[4,5-c]pyridin-7-yl)boronic acid

Product 1

HCID 16660903HCID 16660903, compound

Procedure

The title compound, MS: m/e=354.3 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-2-methyl-thiazolo[4,5-c]pyridine-7-boronic acid (Example D), 3-bromo-5-methylpyridine and 4-amino-2-methylthiazole (Example C).

Sources & evidence

ORD record
ord-decbcaea17414345a4bfeb9e722b0fc3
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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