3,5-Dimethylisoxazole-4-boronic acid → HCID 16661053, compound

HRID 1443101Notes

Reaction equation

HRID 1443101 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[CH3:13][C:14]1[C:18](B(O)O)=[C:17]([CH3:22])[O:16][N:15]=1.[NH2:23][C:24]1[N:25]=[C:26]([CH3:29])[S:27][CH:28]=1>>[CH3:13][C:14]1[C:18]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:23][C:24]3[N:25]=[C:26]([CH3:29])[S:27][CH:28]=3)=[N:3][CH:4]=2)=[C:17]([CH3:22])[O:16][N:15]=1

Participants

4

Reactant 3

HCID 27343463,5-Dimethylisoxazole-4-boronic acidHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16661053HCID 16661053, compound

Procedure

The title compound, MS: m/e=358.1 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3,5-dimethylisoxazole-4-boronic acid and 4-amino-2-methylthiazole (Example C).

Sources & evidence

ORD record
ord-f704b03bc0054e71902068ec1e41ffbc
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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