反应详情

2-Methyl-5-trimethylsilanylethynyl-thiazole-4-carbonitrile (4.56 g, 20.7 mmol) was dissolved in 45 ml methanol and sodium methoxide (5.4N in methanol, 11.5 ml, 62 mmol) was added. The reaction mixture was stirred for 2 hrs at reflux and extracted two times with ethyl acetate and saturated NaHCO3-solution. The organic extracts were dried with sodium sulfate, filtered and evaporated. The crude product (4.5 g, >100%) was used without any further purification for the next step.

1. temperatureat reflux
2. extractionextracted two times with ethyl acetate and saturated NaHCO3-solution
3. dry with materialThe organic extracts were dried with sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe crude product (4.5 g, >100%) was used without any further purification for the next step