反应详情

5-(2,2-Dimethoxy-ethyl)-2-methyl-thiazole-4-carboxylic acid amide (1.0 g, 4.3 mmol) was dissolved in 35 ml dioxane and 0.3 ml conc. sulfuric acid was added. The reaction mixture was stirred for 2 hrs at room temperature. The white suspension was cooled to 0° C. and stirred for 10 min. The suspension was filtered and washed with cold dioxane. The solid was dried for 1 hour at 50° C. and <30 mbar. The desired product was obtained as a white solid (0.7 g, 97%), MS: m/e=167.1 (M+H+).

1. temperatureThe white suspension was cooled to 0° C.
2. stirringstirred for 10 min
3. filtrationThe suspension was filtered
4. washwashed with cold dioxane
5. customThe solid was dried for 1 hour at 50° C.