反应详情

温度

5 °C

2-Methyl-5H-thiazolo[4,5-c]pyridin-4-one (770 mg, 4.6 mmol) was suspended in 25 ml acetonitrile and N-iodosuccinimide (1.04 g, 4.6 mmol) was added. The reaction mixture was refluxed for 3 hrs. The brown suspension was cooled to 5° C. and stirred for 15 min. The solid was filtered, washed with cold acetonitrile and dried for 1 hour at 50° C. and <30 mbar. The crude product (830 mg, 61%) [MS: m/e=292.9 (M+H+)] was used without any further purification for the next step.

1. temperatureThe reaction mixture was refluxed for 3 hrs
2. filtrationThe solid was filtered
3. washwashed with cold acetonitrile
4. customdried for 1 hour at 50° C.
5. customThe crude product (830 mg, 61%) [MS: m/e=292.9 (M+H+)] was used without any further purification for the next step