反应详情

25.66 g (166.47 mmol) of 2-fluoro-3-methoxybenzaldehyde is dissolved in 140 ml of ethanol and mixed in portions at 0° C. with 3.15 g (83.35 mmol) of sodium borohydride. After one hour of stirring at room temperature, the reaction mixture is mixed with water and extracted three times with methyl tert-butyl ether. The combined organic extracts are shaken with water and brine, dried, the desiccant is suctioned off, and the solvent is spun off. The remaining residue is chromatographed on silica gel (mobile solvent:ethyl acetate/hexane). 24.79 g (95.3%) of the desired compound is obtained.

1. extractionextracted three times with methyl tert-butyl ether
2. stirringThe combined organic extracts are shaken with water and brine
3. customdried
4. customThe remaining residue is chromatographed on silica gel (mobile solvent:ethyl acetate/hexane)