Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydrazine Sulfate | HCID 24842 | — |
| Reactant | 3-Bromo-4-nitrophthalide | HCID 17985038 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Nitrophthalazin-1(2H)-one | HCID 20323190 | 43.8% |
Reaction Steps
18.25 g of hydrazine sulfate and 14.88 g of sodium carbonate are stirred in 300 ml of DMF at 100° C. for 1 hour. Then, 7.24 g of 3-bromo-4-nitro-phthalide in 100 ml of DMF is added, and it is stirred for another 4 hours at 100° C. It is added to water, extracted several times with ethyl acetate, and the organic phase is washed with water and brine. It is dried, and the solvent is removed in a vacuum. After recrystallization from ethyl acetate, 2.35 g of 5-nitro-phthalazin-1-one is obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07659297B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-845e9b829188490cbebe2929434f850a |
|---|
| Source note | uspto-grants-2010_02 |
|---|
