Methyl iodide → 1-Chloro-2-methoxy-4-methylbenzene

Participants

Reaction Steps

50 g (350.65 mmol) of 2-chloro-5-methylphenol is dissolved in 450 ml of acetone and mixed under nitrogen with 96.5 g (701.3 mmol) of potassium carbonate. After 43.6 ml of methyl iodide (2 equivalents) is added, it is refluxed for three hours. After cooling, the reaction mixture is filtered, the filter residue is washed with acetone, and the filtrate is spun in until a dry state is reached (bath temperature 30° C.). Since the residue still contains potassium carbonate, it is taken up in a little diethyl ether and filtered repeatedly. After the solvent is spun off, 57 g (103.8%) of the desired compound is obtained, which is incorporated as a crude product into the next stage.

Provenance & Evidence