4-Aminoindolin-2-one → HCID 17989121, compound

HRID 1443239Notes

Reaction equation

HRID 1443239 reaction equation
[OH:1][C:2]([C:20]([F:23])([F:22])[F:21])([CH2:5][C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH3:17])[CH3:16])[C:10]=1[O:18][CH3:19])([CH3:8])[CH3:7])[CH:3]=O.[NH2:24][C:25]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:26]=1[CH2:27][C:28](=[O:34])[NH:29]2>>[OH:1][C:2]([C:20]([F:21])([F:22])[F:23])([CH2:5][C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH3:16])[CH3:17])[C:10]=1[O:18][CH3:19])([CH3:8])[CH3:7])[CH:3]=[N:24][C:25]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:26]=1[CH2:27][C:28](=[O:34])[NH:29]2

Participants

3

Reactant 2

HCID 122374724-Aminoindolin-2-oneHCID 17989257HCID 17989257, compound

Product 1

HCID 17989121HCID 17989121, compoundYield 92.2%

Procedure

250 mg (0.903 mmol) of the 2-hydroxy-4-(3-isopropyl-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-pentanal that is described in Example 162 is reacted with 4-amino-1,3-dihydro-indol-2-one as described in the preceding example and worked up. After chromatography, 334.9 mg (92.2%) of the desired imine is isolated.

Sources & evidence

ORD record
ord-3347b70d8fbc4507b9b7b20697696f02
Source dataset
uspto-grants-2010_02
Patent number
US07659297B2

Reaction notes

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