Ethanol → HCID 17989196, compound

Participants

Reaction Steps

5.44 g (18.84 mmol) of 4-(4-chloro-3-fluoro-2-methoxyphenyl)-4-methyl-2-oxo-pentanoic acid is dissolved in 117 ml of ethanol, mixed with 2.1 ml of concentrated sulfuric acid, and refluxed for six hours. The reaction mixture is added to 250 ml of saturated sodium bicarbonate solution, and extracted three times with ethyl acetate. The combined organic extracts are washed with saturated sodium bicarbonate solution and with brine. After drying, and after the dessicant is filtered off and the solvent is spun in, 5.19 g (87%) of the desired compound is obtained.

Provenance & Evidence