4-(5-Oxopyrrolidin-2-yl)phenyl trifluoromethanesulfonate → HCID 68665529, compound

HRID 1443406Notes

Reaction equation

HRID 1443406 reaction equation
F[C:2](F)(F)S(OC1C=CC(C2NC(=O)CC2)=CC=1)(=O)=O.C(OC([N:28]1[C@@H:32]([C:33]2[CH:38]=[CH:37][C:36]([C:39]#[N:40])=[CH:35][CH:34]=2)[CH2:31][C@H:30]([CH2:41][CH:42]=[CH2:43])[C:29]1=[O:44])=O)(C)(C)C>>[C:39]([C:36]1[CH:35]=[CH:34][C:33]([C@@H:32]2[NH:28][C:29](=[O:44])[C@@H:30]([CH2:41][CH:42]=[CH2:43])[CH2:31]2)=[CH:38][C:37]=1[CH3:2])#[N:40]

Participants

3

Reactant 2

HCID 219184384-(5-Oxopyrrolidin-2-yl)phenyl trifluoromethanesulfonateHCID 68666328HCID 68666328, compound

Product 1

HCID 68665529HCID 68665529, compound

Procedure

The title compound was prepared using a procedure analogous to that described in AMIDOXIME 1, Step B substituting trans-5-(4-trifluoromethanesulfonyloxy-3-methyl-phenyl)-3-(2-propenyl)-2-pyrrolidinone for 5-(4-trifluoromethanesulfonyloxyphenyl)-2-pyrrolidinone: 1H NMR δ 2.06-2.11 (m, 1H), 2.23-2.29 (m, 1H), 2.36-2.42 (m, 1H), 2.55-2.64 (m, 5H), 4.71-4.73 (m, 1H), 5.08-5.14 (m, 2H), 5.74-5.80 (m, 1H), 6.41 (br. s, 1H), 7.18 (d, J=8.0, 11H), 7.23 (br. s, 1H), 7.59 (d, J=7.8, 11H).

Sources & evidence

ORD record
ord-a770c9455c294b8c832ad0148f9b11e8
Source dataset
uspto-grants-2010_02
Patent number
US07659294B2

Reaction notes

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