Anthranilamide → 4-Isopropylthiazole-2-carboxylic acid (2-carbamoyl-phenyl)-amide

HRID 1443427Notes

Reaction equation

HRID 1443427 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:11]([C:14]1[N:15]=[C:16]([C:19](O)=[O:20])[S:17][CH:18]=1)([CH3:13])[CH3:12]>>[C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[NH:1][C:19]([C:16]1[S:17][CH:18]=[C:14]([CH:11]([CH3:13])[CH3:12])[N:15]=1)=[O:20])(=[O:5])[NH2:6]

Participants

3

Reactant 2

HCID 6942AnthranilamideHCID 224993072-Thiazolecarboxylic acid, 4-(1-methylethyl)-

Product 1

HCID 591654734-Isopropylthiazole-2-carboxylic acid (2-carbamoyl-phenyl)-amideYield 56.8%

Procedure

2-Aminobenzamide (2.04 g, 15 mmol) was reacted with 4-isopropylthiazole-2-carboxlic acid (2.5 g, 14.6 mmol) as described in example 6 which gave the title compound (2.4 g, 56%).

Sources & evidence

ORD record
ord-fa474224efbb4f198138ef988b2c050f
Source dataset
uspto-grants-2010_02
Patent number
US07659245B2

Reaction notes

Loading…