反应详情

温度

80 °C

A suspension of compound 57 (2.1 g, 18 mmol) and 3-bromopyruvic acid (3.0 g, 18 mmol) in dioxane (180 mL) was heated to 80° C. Upon reaching 80° C. the mixture became clear, and soon thereafter the product started to precipitate as a white solid. After 2 h of heating, the reaction mixture was cooled to rt and the precipitate was filtered off and collected. This yielded pure title compound (4.4 g, 94%).

1. customUpon reaching 80° C.
2. customto precipitate as a white solid
3. temperatureAfter 2 h of heating
4. temperaturethe reaction mixture was cooled to rt
5. filtrationthe precipitate was filtered off
6. customcollected