HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-2-((1S 2R)1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert.butyl ester → 5-((1R,2S)-1-tert-Butoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-2-((1S 2R)1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert.butyl ester | HCID 57563804 | — |
| Reactant | (1R,4S)-4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid 2-methyl ester | HCID 68410381 | — |
| Reactant | (1R,2S)-1-amino-2-vinyl-cyclo-propane carboxylic acid tert-butyl ester | HCID 68494585 | — |
| Product | 5-((1R,2S)-1-tert-Butoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid methyl ester | HCID 59204196 | — |
Reaction Steps
Reaction of compound 63 (50 mg, 37 mmol) with (1R,2S)-1-amino-2-vinyl-cyclo-propane carboxylic acid tert-butyl ester according to the method described for the preparation of 59 provided the title compound as a slightly yellow oil (50 mg, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659245B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-a7434f9a84b04c93b2836b0d19f99619 |
| Source note | uspto-grants-2010_02 |