Cyclopropanesulfonamide → HCID 76593241, compound

HRID 1443462Notes

Reaction equation

[CH:1]1([S:4]([NH2:7])(=[O:6])=[O:5])[CH2:3][CH2:2]1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:24]=[C:23]([O:25][CH:26]3[CH2:44][CH:43]4[N:28]([C:29](=[O:58])[N:30]([CH2:49][C:50]5[CH:55]=[CH:54][C:53]([O:56][CH3:57])=[CH:52][CH:51]=5)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH:36]=[CH:37][CH:38]5[C:40]([C:46](O)=[O:47])([NH:41][C:42]4=[O:45])[CH2:39]5)[CH2:27]3)[C:22]3[C:17](=[C:18]([CH3:61])[C:19]([O:59][CH3:60])=[CH:20][CH:21]=3)[N:16]=2)=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:24]=[C:23]([O:25][CH:26]3[CH2:44][CH:43]4[N:28]([C:29](=[O:58])[N:30]([CH2:49][C:50]5[CH:51]=[CH:52][C:53]([O:56][CH3:57])=[CH:54][CH:55]=5)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH:36]=[CH:37][CH:38]5[C:40]([C:46]([NH:7][S:4]([CH:1]6[CH2:3][CH2:2]6)(=[O:6])=[O:5])=[O:47])([NH:41][C:42]4=[O:45])[CH2:39]5)[CH2:27]3)[C:22]3[C:17](=[C:18]([CH3:61])[C:19]([O:59][CH3:60])=[CH:20][CH:21]=3)[N:16]=2)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 68687276HCID 68687276, compound

Product 1

HCID 76593241HCID 76593241, compoundYield 33%

Procedure

Cyclopropanesulfonamide (99 mg, 0.8 mmol) was coupled to the acid 102 (200 mg. 0.27 mmol) as described in example 21. Purification by HPLC gave the title compound (75 mg, 33%).

Workup

customPurification by HPLC

Sources & evidence

ORD record: ord-da46a8b48af141cea14632d84f15f21c
Source dataset: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07659245B2

Reaction notes

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