Nitric Acid → HCID 57687233, compound

Participants

Reaction Conditions

Reaction Steps

Compound 105 (33.2 g, 142 mmol) was dissolved in cold concentrated sulphuric acid (70 ml) and 98% nitric acid (9.8 g) was added drop wise while cooling to keep the temperature below 10° C. The mixture was stirred for one hour at about 5° C. The mixture was added to ice water and extracted three times with ethyl acetate. The organic phase was washed twice with brine, dried with sodium sulphate and evaporated under reduced pressure. The product was isolated by column chromatography on silica gel eluted with hexane-ethyl acetate.

Provenance & Evidence