HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanesulfonamide → Cyclopropanesulfonic acid {17-[7-methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanesulfonamide | HCID 15765418 | — |
| Reactant | 17-[7-Methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carboxylic acid | HCID 68424489 | — |
| Product | Cyclopropanesulfonic acid {17-[7-methoxy-8-methyl-2-(6-methyl-pyridin-2-yl)-quinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.0*4,6*]octadec-7-ene-4-carbonyl}-amide | HCID 75290662 | 22.6% |
Reaction Steps
Compound 118 (50 mg, 0.08 mmol) was reacted with cyclopropanesulfonic acid amide (44 mg, 0.36 mmol) according to the procedure described in Example 53 which gave the title compound (13 mg, 22%). MS (M−H)+ 718.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659245B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-663fb556de6247279473b72d4e3bb84f |
| Source note | uspto-grants-2010_02 |