HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 73436958, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Methylcyclopropane-1-sulfonamide | HCID 21889814 | — |
| Reactant | HCID 68408720 | HCID 68408720 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 73436958 | HCID 73436958 | 22% |
Reaction Steps
The acid (130) (35 mg, 0.056 mmol) was dissolved in DCM (2 ml). EDAC (13 mg, 0.067 mmol) was added and the mixture was stirred at room temperature over night. Methylcyclopropanesulfonic acid amide (8.2 mg, 0.061 mmol) and DBU (18 μl, 0.117 mmol) was added and the reaction mixture was stirred at room temperature over night. 5% Citric acid was added to the reaction mixture, and the mixture was extracted with brine, dried over Na2SO4 and purified by HPLC to give the title compound (9 mg, 22%). MS (M+H)=747.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659245B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-dd8d7a3eca884cf29b14632b350ab813 |
| Source note | uspto-grants-2010_02 |