Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 1-Bromo-3-methylbutan-2-one | HCID 10899037 | — |
| Reactant | HCID 68410363 | HCID 68410363 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68409047 | HCID 68409047 | 57.2% |
Reaction Steps
Compound 136 (420 mg, 0.639 mmol) was dissolved in a 96 mL solvent mixture (THF 2:methanol 1:water 1). Aqueous lithium hydroxide (6.4 mL, 1M) was added and the reaction mixture was heated at 50° C. over-night. Purification by column chromatography (silica gel, 5% methanol in dichloromethane) gave the title compound (230 mg, 57%). MS (M+H)+ 629.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07659245B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-a03e5df9b443497d8e320c6f34a00f24 |
|---|
| Source note | uspto-grants-2010_02 |
|---|
