1,1'-Carbonyldiimidazole → HCID 73407442, compound

Participants

Reaction Conditions

Reaction Steps

The acid 137 (130 mg, 0.207 mmol) and N,N,-carbonyldiimidazole (43 mg, 0.26 mmol) in THF (7 mL) were heated to reflux for 2 hours. DBU (29 μl), and cyclopropanesulfonamide, prepared as described in WO03/053349, (28 mg, 0.23 mmol) was then added and the mixture was stirred at 60° C. over-night. The reaction mixture was diluted with ethyl acetate (25 mL) and washed with 0.5 M citric acid. Purification by HPLC gave 30 mg of the title compound. MS (M+H)+ 732.

Provenance & Evidence