HRID1443499

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCCCCN(C)C(=O)C1CC(O)CC1C(=O)NC1(C(=O)OCC)CC1C=C

HCID66870607

未命名化合物

HCID178467466

未命名化合物

PRODUCTS

生成物

结构：CCOc1nc(OC2CC3C(=O)NC4(C(=O)O)CC4C=CCCCCN(C)C(=O)C3C2)c2ccc(OC)c(C)c2n1

HCID68409293

未命名化合物

PROCEDURE

实验过程

Reaction of the quinazolinol (148) and the alcohol (143) according to the procedure described in examples 144-146, gave the title compound m/z=567 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b86dd425a71a4f48afa3e5207042937b
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659245B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH2:1]([O:3][C:4]1[N:13]=[C:12]([OH:14])[C:11]2[C:6](=[C:7]([CH3:17])[C:8]([O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=1)[CH3:2].C([O:20][C:21]([C:23]1([NH:28][C:29]([CH:31]2[CH2:35][CH:34](O)[CH2:33][CH:32]2[C:37](=[O:46])[N:38]([CH2:40][CH2:41][CH2:42][CH2:43][CH:44]=[CH2:45])[CH3:39])=[O:30])[CH2:25][CH:24]1C=C)=[O:22])C>>[CH2:1]([O:3][C:4]1[N:13]=[C:12]([O:14][CH:34]2[CH2:35][CH:31]3[CH:32]([C:37](=[O:46])[N:38]([CH3:39])[CH2:40][CH2:41][CH2:42][CH2:43][CH:44]=[CH:45][CH:25]4[C:23]([C:21]([OH:20])=[O:22])([NH:28][C:29]3=[O:30])[CH2:24]4)[CH2:33]2)[C:11]2[C:6](=[C:7]([CH3:17])[C:8]([O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=1)[CH3:2]