1-{[2-(Hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester → 17-[2-Ethoxy-7-methoxy-8-methylquinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

HRID 1443499Notes

Reaction equation

HRID 1443499 reaction equation
[CH2:1]([O:3][C:4]1[N:13]=[C:12]([OH:14])[C:11]2[C:6](=[C:7]([CH3:17])[C:8]([O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=1)[CH3:2].C([O:20][C:21]([C:23]1([NH:28][C:29]([CH:31]2[CH2:35][CH:34](O)[CH2:33][CH:32]2[C:37](=[O:46])[N:38]([CH2:40][CH2:41][CH2:42][CH2:43][CH:44]=[CH2:45])[CH3:39])=[O:30])[CH2:25][CH:24]1C=C)=[O:22])C>>[CH2:1]([O:3][C:4]1[N:13]=[C:12]([O:14][CH:34]2[CH2:35][CH:31]3[CH:32]([C:37](=[O:46])[N:38]([CH3:39])[CH2:40][CH2:41][CH2:42][CH2:43][CH:44]=[CH:45][CH:25]4[C:23]([C:21]([OH:20])=[O:22])([NH:28][C:29]3=[O:30])[CH2:24]4)[CH2:33]2)[C:11]2[C:6](=[C:7]([CH3:17])[C:8]([O:15][CH3:16])=[CH:9][CH:10]=2)[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 668706071-{[2-(Hex-5-enyl-methyl-carbamoyl)-4-hydroxy-cyclopentanecarbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl esterHCID 178467466HCID 178467466, compound

Product 1

HCID 6840929317-[2-Ethoxy-7-methoxy-8-methylquinazolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

Procedure

Reaction of the quinazolinol (148) and the alcohol (143) according to the procedure described in examples 144-146, gave the title compound m/z=567 (M+H)+.

Sources & evidence

ORD record
ord-b86dd425a71a4f48afa3e5207042937b
Source dataset
uspto-grants-2010_02
Patent number
US07659245B2

Reaction notes

Loading…