1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 75290664, compound

Participants

Reaction Steps

The acid 178 (67 mg, 0.11 mmol) and EDAC (26 mg, 0.13 mmol) were dissolved in dichloromethane (3 ml). After stirring at room temperature for 5 h the mixture was diluted with dichloromethane (10 ml) and the organic phase were washed with water and dried (sodium sulphate). The volume was then reduced to 2 ml and cyclopropyl sulphonamide (20 mg, 0.17 mmol) and DBU (36 mg, 2.3 mmol) were added. The mixture was allowed to stir over-night at room temperature and then washed using 5% aqueous citric acid. Purification by chromatography (0 to 2% methanol in dichloromethane gave the title compound (57 mg, 73%), MS (M+H)+ 704.

Provenance & Evidence