反应详情

43.4 g (0.267 mol) of bromine was added dropwise to a solution of 50.5 g (0.267 mol) of 2′,4′-dichloroacetophenone in 100 g of methanol at a reaction temperature of 45 to 50° C. After the addition was complete, the methanol was evaporated off from the reaction solution under reduced pressure. The resultant concentrate was dissolved in 120 g of toluene and was then washed with water (100 ml×3 times). Thereafter, the toluene was distilled off under reduced pressure, giving 68.0 g (0.254 mol) of crude brown oily 2-bromo-2′,4′-dichloroacetophenone.

1. additionAfter the addition
2. customthe methanol was evaporated off from the reaction solution under reduced pressure
3. concentrationThe resultant concentrate
4. dissolutionwas dissolved in 120 g of toluene
5. washwas then washed with water (100 ml×3 times)
6. distillationThereafter, the toluene was distilled off under reduced pressure