反应详情

51.4 g (0.322 mol) of bromine was added dropwise to a solution of 63.2 g (0.311 mol) of 2′,4′-dichloropropiophenone in 140 g of methanol at a reaction temperature of 50 to 55° C. After the addition was complete, the methanol was evaporated off from the reaction solution under reduced pressure. The resultant concentrate was dissolved in 120 g of toluene and was then washed with water (150 ml×3 times). Thereafter, the toluene was distilled off under reduced pressure, giving 85.2 g (0.302 mol) of crude brown oily 2-bromo-2′,4′-dichloropropiophenone.

1. additionAfter the addition
2. customthe methanol was evaporated off from the reaction solution under reduced pressure
3. concentrationThe resultant concentrate
4. dissolutionwas dissolved in 120 g of toluene
5. washwas then washed with water (150 ml×3 times)
6. distillationThereafter, the toluene was distilled off under reduced pressure