Benzamidine, hydrochloride → HCID 23103026, compound

Participants

Reaction Steps

A solution of 86.6 g (0.307 mol) of the above-mentioned crude 2-bromo-3′,4′-dichloropropiophenone in 120 ml of tetrahydrofuran was added dropwise over 40 minutes into a suspension, under reflux with heating, of 48.1 g (0.307 mol) of benzamidine hydrochloride, 123.4 g (1.23 mol) of potassium bicarbonate in 450 ml of tetrahydrofuran and 110 ml of water. After the addition was complete, further refluxing with heating was carried out for 2 hours. The reaction solution was evaporated to dryness under reduced pressure, to give a residual solid. This solid was successively washed with water and toluene, to give 65.3 g (71.3% crude yield) of crude crystals of the desired product. The crude crystals were recrystallized using acetonitrile, to give a purified white powder.

Provenance & Evidence