Hydrochloric Acid → 2-(2,2,3,4,4,4-Hexafluorobutyl)-2-(2,2,3,3,4,4,5,5-octafluoropentyl)malononitrile

Participants

Reaction Steps

1.4 g of 2-(2,2,3,3,4,4,5,5-octafluoropentyl)malononitrile and 3.1 g of 2,2,3,4,4,4-hexafluorobutyl trifluoromethanesulfonate were dissolved in 10 ml of ethylene glycol dimethyl ether, 0.97 g of potassium carbonate was added, and the mixture was stirred at room temperature for 7 hours. Thereafter, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with methyl tert-butyl ether. The organic layer was washed successively with water, aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.06 g of 2-(2,2,3,4,4,4-hexafluorobutyl)-2-(2,2,3,3,4,4,5,5-octafluoropentyl)malononitrile (hereinafter, referred to as the present compound (81)).

Provenance & Evidence