Trifluoromethanesulfonic anhydride → 4,4,5,5,5-Pentafluoropentyl trifluoromethanesulfonate

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Reaction Steps

At 0° C., 18.6 g of trifluoromethanesulfonic anhydride was added dropwise to 10.7 g of 4,4,5,5,5-pentafluoropentanol. The mixture was stirred at room temperature for an hour and then at 80° C. for 2 hours. Thereafter, the reaction mixture was poured into ice water and then extracted with t-butyl methyl ether. The organic layer was washed successively with water, aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 6.2 g of 4,4,5,5,5-pentafluoropentyl trifluoromethanesulfonate.

Provenance & Evidence