反应详情

Concentrated sulfuric acid (5.0 mL) was added to an ethanol suspension (150 mL) of trans-4-(2-(trans-4-propylcyclohexyl)ethyl)cyclohexanecarboxylic acid (50.0 g), and the resultant was thereafter heated and refluxed for six hours. It was cooled to room temperature to halt the reaction by the addition of water. An organic layer was extracted by using ethyl acetate. The thus collected organic layer was washed by using a saturated sodium bicarbonate aqueous solution and brine in that order, and dried with anhydrous sodium sulphate. Solvents were removed by distillation to obtain a slightly yellow solid of 55.1 g.

1. temperaturethe resultant was thereafter heated
2. temperaturerefluxed for six hours
3. customthe reaction
4. extractionAn organic layer was extracted
5. washThe thus collected organic layer was washed
6. dry with materialdried with anhydrous sodium sulphate
7. customSolvents were removed by distillation
8. customto obtain a slightly yellow solid of 55.1 g