HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dextroamphetamine → Lisdexamfetamine Dimesylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dextroamphetamine | HCID 5826 | — |
| Reactant | Amphedrine | HCID 222898 | — |
| Reactant | L-lysine d-amphetamine | HCID 131727865 | — |
| Solvent | Water | HCID 962 | — |
| Product | Lisdexamfetamine Dimesylate | HCID 11597697 | — |
Reaction Steps
Male Sprague-Dawley rats were provided water ad libitum, fasted overnight, and dosed by oral gavage with 1.5, 3, 6, 12, and 60 mg/kg of amphetamine sulfate or L-lysine-d-amphetamine containing the equivalent amounts of d-amphetamine. Concentrations of d-amphetamine were measured by ELISA.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662788B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-1d3ea0f816d24609872bb8cfd6622ae2 |
| Source note | uspto-grants-2010_02 |