反应详情

Add a solution of thiobenzoylsulfanylacetic acid (5.5 g, 26.0 mmol) in methanol (100 mL) and to a solution of thionyl chloride (52 mL) at room temperature under nitrogen and heat the mixture at reflux for 12 hours. Remove the solvent under reduced pressure, dissolve the residue in ethyl acetate (200 mL), wash with saturated NaHCO3 (200 mL) and brine (200 mL) solutions, and dry over sodium sulfate. Remove the solvent under reduced pressure to provide thiobenzoylsulfanylacetic acid methyl ester (5.7 g, 97%).

1. temperatureat reflux for 12 hours
2. customRemove the solvent under reduced pressure
3. dissolutiondissolve the residue in ethyl acetate (200 mL)
4. washwash with saturated NaHCO3 (200 mL) and brine (200 mL) solutions
5. dry with materialdry over sodium sulfate
6. customRemove the solvent under reduced pressure