反应详情

Add aluminum(III) chloride (3.84 g, 29 mmol) to a suspension of 8-[4-(2-isopropoxyphenyl)imidazol-1-yl]octanoic acid methyl ester (5.16 g, 14 mmol) in methylene chloride (150 mL) at 0° C. under nitrogen. Warm the mixture to room temperature and stir for 6 hours. Dilute the mixture with saturated aqueous sodium sulfate (50 mL) and remove the solvent under reduced pressure. Dilute the residue with ethyl acetate (300 mL), wash with brine (100 mL), dry over sodium sulfate, and remove the solvent under reduced pressure. Purify the residue by flash column chromatography on silica gel, eluting with ethyl acetate/hexanes (2:8 to 3:7), to provide 8-[4-(2-hydroxyphenyl)imidazol-1-yl]octanoic acid methyl ester (2.63 g, 57%).

1. customremove the solvent under reduced pressure
2. additionDilute the residue with ethyl acetate (300 mL)
3. washwash with brine (100 mL)
4. dry with materialdry over sodium sulfate
5. customremove the solvent under reduced pressure
6. customPurify the residue by flash column chromatography on silica gel
7. washeluting with ethyl acetate/hexanes (2:8 to 3:7)