Hydrogen Bromide → HCID 68494378, compound

Participants

Reaction Steps

Dissolve 5-[4-(2-methoxy-phenyl)-thiazol-2-yl]-pentanoic acid methyl ester (3.20 g, 10.5 mmol) in acetic acid (50 mL, glacial), add HBr (50 mL, 48% aqueous solution) and heat to reflux under N2 for 6 hours. Add additional HBr (20 mL, 48% aqueous solution) and heat at reflux under N2 overnight. Adjust to pH 4 with 5N NaOH solution, extract with EtOAc (×2), dry over MgSO4 and concentrate to get 2.64 grams of a light brown solid. Recrystallize from EtOAc/hexanes to afford the title compound (2.14 g, 74%). MS (IS) 278 (M+1)+.

Provenance & Evidence