Benzylamine → Benzyl-(1-amino-3-chloro-2-propanol)

HRID 1443761Notes

Reaction equation

HRID 1443761 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH2:6]([NH2:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH2:6]([NH:13][CH2:4][CH:3]([OH:5])[CH2:1][Cl:2])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 7835Epichlorohydrin

Product 1

HCID 173441Benzyl-(1-amino-3-chloro-2-propanol)Yield 43%

Procedure

Epichlorohydrin (39 ml, 0.5 mol) and benzylamine (54.6 ml, 0.5 mol) were dissolved in petroleum ether (500 ml), stirred at room temperature for 48 hours, and filtered. The resulting solid product was dissolved in toluene (50 ml), and normal hexane (500 ml) was added to the resulting solution to obtain the title compound as a crystalline form in a yield of 43%.

Workup

  1. filtrationfiltered
  2. dissolutionThe resulting solid product was dissolved in toluene (50 ml)
  3. additionnormal hexane (500 ml) was added to the resulting solution

Sources & evidence

ORD record
ord-586f23013f9044bea832bbcd68a12f19
Source dataset
uspto-grants-2010_02
Patent number
US07662810B2

Reaction notes

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