Sodium Hydroxide → HCID 11515470, compound

Participants

Reaction Steps

A mixture of N-{4-[6-(9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-pyridazin-3-ylethynyl]-phenyl}-acetamide (0.42 g, 1.11 mmol), aqueous sodium hydroxide (10 ml, 4 M) and ethanol (10 ml, 96%) was stirred for 2 hours at reflux. The mixture was evaporated. Water (30 ml) was added and the mixture was extracted twice with dichloromethane (2×30 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound. Yield 0.30 g (80%). Mp. 191° C.

Provenance & Evidence