HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chlorophenyl)piperazine → Methyl {2-[4-(3-chlorophenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| Reactant | Methyl (2E)-3-{3-[({[3-(trifluoromethyl)phenyl]imino}methylene)amino]pyridin-4-yl}acrylate | HCID 86620420 | — |
| Product | Methyl {2-[4-(3-chlorophenyl)piperazin-1-yl]-3-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrido[3,4-d]pyrimidin-4-yl}acetate | HCID 59168057 | — |
Reaction Steps
Starting from 250 mg (0.34 mmol) of the carbodiimide from Example 17A and 71 mg (0.36 mmol) of 3-chlorophenylpiperazine, general procedure [C] and purification by preparative HPLC result in 102 mg (53% of theory) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07662822B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-201e59e58538454b99cecf88ec1b4f17 |
| Source note | uspto-grants-2010_02 |