反应详情

A suspension of 7-chloro-pyrazolo-[1,5-a]-pyrimidine-5-carboxylic acid ethyl ester (15.0 g), sodium acetate (6.54 g), and 10% palladium on carbon (665 mg) in ethyl acetate-ethanol (1-1.50 mL) was stirred under a hydrogen atmosphere. After the completion of the reaction, the reactant was filtered, and concentrated in vacuo. The residue was dissolved in ethyl acetate, washed with water, aqueous baking soda, and brine, dried with sodium sulfate, and concentrated in vacuo. The yellow residue was recrystallized to yield a light yellow needle crystal (9.9 g, 78%). mp:114-115° C.

1. customAfter the completion of the reaction
2. filtrationthe reactant was filtered
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwashed with water, aqueous baking soda, and brine
6. dry with materialdried with sodium sulfate
7. concentrationconcentrated in vacuo
8. customThe yellow residue was recrystallized