Trifluoroacetic acid → HCID 58628306, compound

Participants

Reaction Steps

A solution of N-{2-(4-t-butoxycarbonyl piperazino)phenyl}methyl 3-(3-chlorophenyl)-pyrazolo-[1,5-a]-pyrimidine-6-amide (300 mg) and trifluoroacetic acid (0.42 ml) in chloroform (6 ml) was heated at reflux over 6 hours. The reactant was cooled, and ice and a 2N aqueous sodium hydroxide solution (3 ml) were added, and thereafter extracted with chloroform. The organic layer was dried with magnesium sulfate, and thereafter the solvent was distilled under a reduced pressure. The residue was purified by an alumina column chromatography, and thereafter recrystallized from tetrahydrofuran-diisopropyl ether to yield N-(2-piperazinophenyl)methyl 3-(3-chlorophenyl)-pyrazolo-[1,5-a]-pyrimidine-6-amide (220 mg, 90%). mp: 185-188° C.

Provenance & Evidence