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HRID1443867

反应详情

EQUATION

反应方程式

HRID 1443867 的结构方程式

REACTANTS

反应物

2
反应SMILES：O=C(c1ccccn1)N1CCNCC1
HCID181639

(Piperazin-1-yl)(pyridin-2-yl)methanone

C10H13N3O

反应SMILES：COc1cnc(Cl)c2[nH]cc(C(=O)C(=O)[O-])c12.[K+]
HCID22893812

未命名化合物

PRODUCTS

产物

1
反应SMILES：COc1cnc(Cl)c2[nH]cc(C(=O)C(=O)N3CCN(C(=O)c4ccccn4)CC3)c12
HCID59693850

未命名化合物

PROCEDURE

实验过程

Precursor 5l, 1-picolinoyl-4-[(4-methoxy-7-chloro-6-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a starting from Potassium (4-methoxy-7-chloro-6-azaindol-3-yl)oxoacetate, Precursor 4d, and picolinoyl-piperazine. 1H NMR (500 MHz, DMSO-d6) δ8.63-7.45 (m, 7H), 3.94 (s, 3H), 3.82-2.50 (m, 8H). MS m/z: (M+H)+ Calc'd for C20H19ClN5O4: 428.11; Found 428. 11. HPLC retention time: 1.09 minutes (column A).