HCID 59693965, compound → HCID 59693942, compound

HRID 1443868Notes

Reaction equation

HRID 1443868 reaction equation
[Br:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:11](=[O:15])[C:12]([O-:14])=O.[K+].[CH3:17][C@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24](=[O:31])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:19]1>>[N:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[C:24]([N:20]1[CH2:21][CH2:22][N:23]([C:12](=[O:14])[C:11]([C:7]2[C:6]3[C:10](=[C:2]([Br:1])[N:3]=[CH:4][CH:5]=3)[NH:9][CH:8]=2)=[O:15])[C@H:18]([CH3:17])[CH2:19]1)=[O:31]

Participants

3

Reactant 2

HCID 59693965HCID 59693965, compoundHCID 59915963HCID 59915963, compound

Product 1

HCID 59693942HCID 59693942, compound

Procedure

Precursor 5m, (R)-1-picolinoyl-3-methyl-4-[(7-bromo-6-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a starting from Potassium (7-bromo-6-azaindol-3-yl)oxoacetate, Precursor 4g, and (R)-3-methyl-1-picolinoyl-piperazine. MS m/z: (M+H)+ Calc'd for C20H19BrN5O3: 456.07; Found 456. 11. HPLC retention time: 1.12 minutes (column A).

Sources & evidence

ORD record
ord-d8dcce293076423f8473418edcc3d51f
Source dataset
uspto-grants-2010_02
Patent number
US07662823B2

Reaction notes

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