2-(Tributylstannyl)-1,3-thiazole → HCID 67152779, compound

HRID 1443875Notes

Reaction equation

HRID 1443875 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([C:13](=[O:28])[C:14]([C:16]2[C:24]3[C:19](=[C:20](Cl)[N:21]=[CH:22][C:23]=3[O:25][CH3:26])[NH:18][CH:17]=2)=[O:15])[CH2:9][CH2:8]1.[S:29]1[CH:33]=[CH:32][N:31]=[C:30]1[Sn](CCCC)(CCCC)CCCC>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([C:13](=[O:28])[C:14]([C:16]2[C:24]3[C:19](=[C:20]([C:30]4[S:29][CH:33]=[CH:32][N:31]=4)[N:21]=[CH:22][C:23]=3[O:25][CH3:26])[NH:18][CH:17]=2)=[O:15])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 86590119HCID 86590119, compound

Product 1

HCID 67152779HCID 67152779, compound

Procedure

Example 50, was prepared from 1-(pyridin-2-yl)-4-[(4-methoxy-7-chloro-6-azaindol-3-yl)-oxoacetyl]piperazine and thiazol-2-yl tributyltin, Precursor 14a-21, according to the general method above to provide 1-(pyridin-2-yl)-4-[(4-methoxy-7-(thiazol-2-yl)-6-azaindol-3-yl)-oxoacetyl]piperazine MS m/z: (M+H)+ Calc'd for C24H25N6O4S: 477.13; found 477.22. HPLC retention time: 0.98 minutes (column A).

Sources & evidence

ORD record
ord-42f1c06ad8254c5c9dfadf5aef7cb2fd
Source dataset
uspto-grants-2010_02
Patent number
US07662823B2

Reaction notes

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