Aluminium lithium hydride → HCID 44248849, compound

Participants

Reaction Steps

A solution of 2-nitro-8-oxo-5,6,9,10,11,12-hexahydro-4H,8H-cyclohepta[4,5]pyrrolo[3,2,1-ij]quinoline (0.17 g, 0.60 mmol; prepared in Example 23, Step 1) in dioxane (5 mL) is added dropwise to a refluxing slurry of LiAlH4 (0.24 g, 6 mmol) in dioxane (20 mL). The reaction mixture was refluxed overnight. After cooling to ambient temperature, the mixture was poured onto ice water and extracted with ethyl acetate. The combined organic extracts were dried over MgSO4 and concentrated to give 0.11 g of 5,6,9,10,11,12-hexahydro-4H,8H-cyclohepta[4,5]pyrrolo[3,2,1-ij]quinolin-2-amine.

Provenance & Evidence