HCID 59168389, compound → HCID 59168388, compound

HRID 1443929Notes

Reaction equation

HRID 1443929 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10]3=[C:11]([CH2:13][CH2:14][N:9]3[C:8]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:7]2=3)[CH:12]=1)([O-])=O>[Pd].C(O)C>[CH:5]1[C:4]([NH2:1])=[CH:12][C:11]2[CH2:13][CH2:14][N:9]3[C:10]=2[C:6]=1[C:7]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:8]=13

Participants

4

Reactant 1

HCID 59168389HCID 59168389, compound

Product 1

HCID 59168388HCID 59168388, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Following the procedure of Example 1, Step 3, 2-nitro-4,5,7,8,9,10,11,12-octahydrocycloocta[b]pyrrolo[3,2,1-hi]indole (2.0 g, 7.4 mmol) and 5% palladium on carbon (0.25 g) in ethanol (25 mL) was hydrogenated to provide 4,5,7,8,9,10,11,12-octahydrocycloocta[b]pyrrolo[3,2,1-hi]indol-2-amine. MS (ES) m/z 241.2; HRMS: calcd for C16H20N2+H+, 241.16992; found (ESI, [M+H]+), 241.1693.

Sources & evidence

ORD record
ord-9d0d2ad78b8e42e189b70d822aac0891
Source dataset
uspto-grants-2010_02
Patent number
US07662831B2

Reaction notes

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