反应详情

N-bromosuccinamide (6.9 g) was added portionwise over 0.5 h to a stirred solution of 6-chloro-2-pyrazinamine (5.0 g) in chloroform (200 mL) heated under reflux. After the addition was complete the reaction mixture was allowed to cool, washed with water and evaporated to give a 3:1 mixture of 5-bromo-6-chloro-2-pyrazinamine and the subtitle compound which were separated by silica gel chromatography eluting with dichloromethane. Yield 2.0 g. Used directly.

1. temperatureheated
2. temperatureunder reflux
3. additionAfter the addition
4. temperatureto cool
5. washwashed with water
6. customevaporated
7. customto give
8. customthe subtitle compound which were separated by silica gel chromatography
9. washeluting with dichloromethane