6-Methyl-2-pyridylmethanol → 2,3-Dichloro-N-[5-methyl-3-(6-methyl-2-pyridinylmethoxy)-2-pyrazinyl]benzenesulphonamide

HRID 1443957Notes

Reaction equation

HRID 1443957 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][CH:3]=1.Br[C:11]1[C:12]([NH:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=2[Cl:29])(=[O:21])=[O:20])=[N:13][CH:14]=[C:15]([CH3:17])[N:16]=1>>[Cl:29][C:23]1[C:24]([Cl:28])=[CH:25][CH:26]=[CH:27][C:22]=1[S:19]([NH:18][C:12]1[C:11]([O:9][CH2:8][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=2)=[N:16][C:15]([CH3:17])=[CH:14][N:13]=1)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 707366-Methyl-2-pyridylmethanolHCID 59168147N-(3-Bromo-5-methyl-2-pyrazinyl)-2,3-dichlorobenzenesulphonamide

Product 1

HCID 101513582,3-Dichloro-N-[5-methyl-3-(6-methyl-2-pyridinylmethoxy)-2-pyrazinyl]benzenesulphonamide

Procedure

Prepared by the method of Example 20 using 6-methylpyridine-2-methanol (0.05 g) and N-(3-bromo-5-methyl-2-pyrazinyl)-2,3-dichlorobenzenesulphonamide (0.1 g). Yield 0.023 g.

Sources & evidence

ORD record
ord-435fb41b8be9422fbbb3d207696519ba
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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