5-(Hydroxymethyl)-1-methyl-1,2-dihydropyridin-2-one → N-[5-Bromo-3-(1-methyl-6-oxo-1,6-dihydro-3-pyridinylmethoxy)-2-pyrazinyl]-2,3-dichlorobenzenesulphonamide

HRID 1443966Notes

Reaction equation

HRID 1443966 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6](=[O:10])[N:7]([CH3:9])[CH:8]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[S:19]([NH:22][C:23]1[C:28](Br)=[N:27][C:26]([Br:30])=[CH:25][N:24]=1)(=[O:21])=[O:20]>>[Br:30][C:26]1[N:27]=[C:28]([O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6](=[O:10])[N:7]([CH3:9])[CH:8]=2)[C:23]([NH:22][S:19]([C:13]2[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=2[Cl:11])(=[O:21])=[O:20])=[N:24][CH:25]=1

Participants

3

Reactant 2

HCID 574158605-(Hydroxymethyl)-1-methyl-1,2-dihydropyridin-2-oneHCID 591682192,3-Dichloro-N-(3,5-dibromo-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 58597368N-[5-Bromo-3-(1-methyl-6-oxo-1,6-dihydro-3-pyridinylmethoxy)-2-pyrazinyl]-2,3-dichlorobenzenesulphonamide

Procedure

Prepared by the method of Example 31 using 5-hydroxymethyl-1-methyl-1H-pyridin-2-one (0.1 g) and 2,3-dichloro-N-(3,5-dibromo-2-pyrazinyl)benzenesulphonamide (0.16 g). Yield 0.035 g.

Sources & evidence

ORD record
ord-522a35ec08ea406fb0f60774086d185a
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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