Water → HCID 11180148, compound

Participants

Reaction Steps

To a stirred solution of 2,3-Dichloro-N-(5,6-dichloro-3-methoxy-2-pyrazinyl)benzenesulphonamide (0.68 g) in dichloromethane (20 mL) was added triethylamine (0.49 mL) followed by 2-(trimethylsilyl)ethoxymethyl chloride (0.328 g) and the resulting mixture was stirred at room temperature for 1 h. The reaction mixture was poured into water (50 mL) and extracted into ethyl acetate (3×20 mL). The combined extracts were dried (MgSO4), filtered and concentrated. Chromatography on silica gel eluting with ethyl acetate/isohexane mixtures gave the sub-title compound as a white solid (0.74 g).

Provenance & Evidence