4-Piperidinemethanol → 2,3-Dichloro-N-[5-(4-hydroxymethyl-1-piperidinyl)-3-methoxy-2-pyrazinyl]benzenesulphonamide
Reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[C:10]1[N:11]=[C:12]([O:36][CH3:37])[C:13]([N:16](COCC[Si](C)(C)C)[S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=2[Cl:27])(=[O:19])=[O:18])=[N:14][CH:15]=1>>[Cl:27][C:21]1[C:22]([Cl:26])=[CH:23][CH:24]=[CH:25][C:20]=1[S:17]([NH:16][C:13]1[C:12]([O:36][CH3:37])=[N:11][C:10]([N:6]2[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]2)=[CH:15][N:14]=1)(=[O:19])=[O:18]Participants
3
Procedure
Prepared by the method of Example 55 using 4-(hydroxymethyl)piperidine (0.4 g) and N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (0.3 g). Yield 0.012 g.
Sources & evidence
- ORD record
- ord-8908bd772406498cacc67cef1ca54a95
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07662825B2
Reaction notes
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