2,3-Dichlorobenzene-1-sulfonyl chloride → 2,3-Dichloro-N-[5-(2,4-difluorophenyl)-3-methoxy-2-pyrazinyl]benzenesulphonamide

HRID 1443996Notes

Reaction equation

HRID 1443996 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([O:16][CH3:17])[C:12]([NH2:15])=[N:13][CH:14]=1.[Cl:18][C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[S:26](Cl)(=[O:28])=[O:27]>>[Cl:18][C:19]1[C:24]([Cl:25])=[CH:23][CH:22]=[CH:21][C:20]=1[S:26]([NH:15][C:12]1[C:11]([O:16][CH3:17])=[N:10][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:14][N:13]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 27342222,3-Dichlorobenzene-1-sulfonyl chlorideHCID 591681725-(2,4-Difluorophenyl)-3-methoxy-2-pyrazinamine

Product 1

HCID 591681332,3-Dichloro-N-[5-(2,4-difluorophenyl)-3-methoxy-2-pyrazinyl]benzenesulphonamide

Procedure

Prepared by the method of Example 1 using 5-(2,4-difluorophenyl)-3-methoxy-2-pyrazinamine (0.2 g) and 2,3-dichlorobenzenesulphonyl chloride (0.2 g). Yield 0.06 g.

Sources & evidence

ORD record
ord-0cc2e55a65d34ff1a16cad19d9b66a9a
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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