2-Chlorobenzyl mercaptan → 2,3-Dichloro-N-[5-(2-chlorobenzylsulphanyl)-3-methoxy-2-pyrazinyl]benzenesulphonamide

HRID 1443999Notes

Reaction equation

HRID 1443999 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][SH:5].Br[C:11]1[N:12]=[C:13]([O:37][CH3:38])[C:14]([N:17](COCC[Si](C)(C)C)[S:18]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=2[Cl:28])(=[O:20])=[O:19])=[N:15][CH:16]=1>>[Cl:28][C:22]1[C:23]([Cl:27])=[CH:24][CH:25]=[CH:26][C:21]=1[S:18]([NH:17][C:14]1[C:13]([O:37][CH3:38])=[N:12][C:11]([S:5][CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[Cl:1])=[CH:16][N:15]=1)(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 5807592-Chlorobenzyl mercaptanHCID 59168156N-(5-Bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide

Product 1

HCID 101957732,3-Dichloro-N-[5-(2-chlorobenzylsulphanyl)-3-methoxy-2-pyrazinyl]benzenesulphonamide

Procedure

Prepared by the method of Example 82 using 2-chlorobenzylmercaptan (0.15 g) and N-(5-bromo -3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (0.4 g). Yield 0.18 g.

Sources & evidence

ORD record
ord-f7c3cfc86e76439eb2769bff58ade27a
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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